See Profile manager (create a new profile), Moving your mail storage location and Shortcut to a specific profile if you want to do that. That way depending upon which Thunderbird shortcut you use you can easily switch configurations with minimal side effects.
One profile would disable features as described below. If you sometimes want to use some of the disabled features when using a broadband connection consider using two profiles which use common directories outside of the profile to store the messages. This configuration is also useful if you have a 3G mobile connection and need to minimize bandwidth usage. It will fetch the contents as needed when you open a message in a remote folder, but it will only store it in memory. If you disable offline folders, global search, and the disk cache Thunderbird will only download headers for messages in remote folders (IMAP account). Thunderbird has several new features which are enabled by default that increase the size of a profile. This article was written for Thunderbird but also applies to Mozilla Suite / SeaMonkey (though some menu sequences may differ).
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